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Enantioselective Synthesis of Propargylamines by Copper‐Catalyzed Addition of Alkynes to Enamines
Author(s) -
Koradin Christopher,
Polborn Kurt,
Knochel Paul
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20020715)41:14<2535::aid-anie2535>3.0.co;2-m
Subject(s) - enantioselective synthesis , copper , catalysis , chemistry , combinatorial chemistry , organic chemistry
Enantiomerically enriched, functionalized, and protected propargylamines are obtained under mild conditions in a new copper( I )/Quinap‐catalyzed addition reaction of alkynes to enamines (see scheme).