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Benzylic endo ‐Alkylation of Phthalan–Cr(CO) 3 Complexes via Temporary Silylation: An Entry to trans ‐1,3‐Disubstituted Dihydroisobenzofurans
Author(s) -
Zemolka Saskia,
Lex Johann,
Schmalz HansGünther
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20020715)41:14<2525::aid-anie2525>3.0.co;2-o
Subject(s) - deprotonation , stereoselectivity , silylation , alkylation , chemistry , scheme (mathematics) , computer science , selectivity , information retrieval , combinatorial chemistry , stereochemistry , medicinal chemistry , organic chemistry , mathematics , catalysis , ion , mathematical analysis
A completely stereoselective synthesis of pharmacologically relevant trans ‐1,3‐disubstituted dihydroisobenzofurans utilizes the surprising selectivity during the benzylic deprotonation of a silylated [phthalan–Cr(CO) 3 ] complex (see scheme).