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Observation of the Direct Products of Migratory Insertion in Aryl Palladium Carbene Complexes and Their Subsequent Hydrolysis
Author(s) -
Albéniz Ana C.,
Espinet Pablo,
Manrique Raúl,
PérezMateo Alberto
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20020703)41:13<2363::aid-anie2363>3.0.co;2-9
Subject(s) - carbene , aryl , intramolecular force , electrophile , carbon atom , hydrolysis , palladium , chemistry , alkyl , migratory insertion , combinatorial chemistry , medicinal chemistry , stereochemistry , organic chemistry , catalysis
The interaction of an electrophilic carbene carbon atom with the π‐electron density of an aryl group favors an intramolecular migratory insertion reaction (see scheme; Pf=C 6 F 5 ). This reaction gives alkyl compounds ( 2 or 3 ) which can be identified prior to their eventual hydrolysis to 4 .