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Monodentate Chiral Spiro Phosphoramidites: Efficient Ligands for Rhodium‐Catalyzed Enantioselective Hydrogenation of Enamides
Author(s) -
Hu AiGuo,
Fu Yu,
Xie JianHua,
Zhou Hai,
Wang LiXin,
Zhou QiLin
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20020703)41:13<2348::aid-anie2348>3.0.co;2-k
Subject(s) - denticity , rhodium , enantioselective synthesis , chemistry , asymmetric hydrogenation , amine gas treating , catalysis , combinatorial chemistry , noyori asymmetric hydrogenation , organic chemistry , crystal structure
Monodentate phosphorus ligands, too, can be effective : Chiral amine derivatives can be obtained in high enantioselectivities (up to 99.7 % ee ) by the asymmetric hydrogenation of enamides in the presence of rhodium complexes of the chiral spiro phosphorus ligands ( S )‐ 1 , the first monodentate P ligands that are effective in this class of reactions.