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Ones, Thiones, and N ‐Oxides: An Exercise in Imidazole Chemistry
Author(s) -
Laufer Stefan,
Wagner Gerd,
Kotschenreuther Dunja
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20020703)41:13<2290::aid-anie2290>3.0.co;2-r
Subject(s) - imidazole , regioselectivity , chemistry , combinatorial chemistry , content (measure theory) , information retrieval , organic chemistry , computer science , catalysis , mathematics , mathematical analysis
Regioselective synthetic approaches to tetrasubstituted imidazoles (see picture) are reported. These highly substituted heterocycles are potent inhibitors of cytokine release and therefore interesting candidates for anti‐inflammatory drugs.