Premium
Small Interfering RNAs and Their Chemical Synthesis
Author(s) -
Micura Ronald
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20020703)41:13<2265::aid-anie2265>3.0.co;2-3
Subject(s) - rna , function (biology) , context (archaeology) , computational biology , small interfering rna , rna interference , chemistry , protein biosynthesis , combinatorial chemistry , computer science , biology , biochemistry , microbiology and biotechnology , gene , paleontology
Improved protecting‐group strategies are used in two successful methods for the synthesis of oligoribonucleotides. The effective production of these compounds is of growing importance in the context of RNA interference, a phenomenon that is exploited for investigations into protein function.