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Catalytic Enantioselective Synthesis of β 2 ‐Amino Acids
Author(s) -
Davies Huw M. L.,
Venkataramani Chandrasekar
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20020617)41:12<2197::aid-anie2197>3.0.co;2-n
Subject(s) - enantioselective synthesis , carbenoid , trifluoroacetic acid , intermolecular force , regioselectivity , catalysis , chemistry , amino acid , stereochemistry , organic chemistry , combinatorial chemistry , biochemistry , rhodium , molecule
A very direct approach for the synthesis of β ‐amino esters is provided by catalytic asymmetric CH activation by means of carbenoid‐induced CH insertion (see scheme; Boc=butyloxycarbonyl; TFA=trifluoroacetic acid). The reactions described herein represent the first regioselective intermolecular CH insertions occurring at a methyl site.