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BuMgN i Pr 2 : A New Base for Stoichiometric, Position‐Selective Deprotonation of Cyclopropane Carboxamides and Other Weak CH Acids
Author(s) -
Zhang MaoXi,
Eaton Philip E.
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20020617)41:12<2169::aid-anie2169>3.0.co;2-h
Subject(s) - deprotonation , cyclopropane , chemistry , stoichiometry , amine gas treating , reagent , base (topology) , alkane , proton , medicinal chemistry , organic chemistry , stereochemistry , hydrocarbon , ring (chemistry) , physics , ion , mathematical analysis , mathematics , quantum mechanics
Using the irreversible formation of an alkane , the proton‐removing ability of a magnesiated amine, and the activating effect of a carboxamido group, weakly acidic CH groups in a variety of systems can be selectively converted into useful amido‐Grignard reagents (see scheme; DAH=dehydrated diisopropylamine).