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A Synthetic Approach towards the C1–C9 Subunit of Zincophorin
Author(s) -
Cossy Janine,
Blanchard Nicolas,
Defosseux Magali,
Meyer Christophe
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20020617)41:12<2144::aid-anie2144>3.0.co;2-e
Subject(s) - hydroboration , aldol reaction , protein subunit , intramolecular force , stereochemistry , chemistry , key (lock) , combinatorial chemistry , biochemistry , biology , catalysis , ecology , gene
Antibiotics made from cyclopropylmethanols : The C1–C9 subunit ( 2 ) of zincophorin ( 1 ) has been synthesized by using three key steps: a hydroboration of an enantiomerically enriched isopropenylcyclopropane, an aldol reaction, and an intramolecular oxymercuration of a cyclopropylmethanol.