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A New Protocol for the Enantioselective Synthesis of Methyl‐Substituted Alkanols and Their Derivatives through a Hydroalumination/Zirconium‐Catalyzed Alkylalumination Tandem Process
Author(s) -
Huo Shouquan,
Shi Jicheng,
Negishi Eiichi
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20020617)41:12<2141::aid-anie2141>3.0.co;2-w
Subject(s) - tandem , enantioselective synthesis , chemistry , catalysis , scheme (mathematics) , hydride , protocol (science) , combinatorial chemistry , stereochemistry , computer science , organic chemistry , mathematics , engineering , medicine , hydrogen , mathematical analysis , alternative medicine , pathology , aerospace engineering
Methyl‐substituted alkanols have been synthesized enantioselectively (90–93 % ee ) in a one‐pot hydroalumination/carboalumination tandem process (see scheme). This enantioselectively represents an increase of about 15 % from the previously attainable ee values. DIBAH = diisobutylaluminum hydride, IBAO = isobutylaluminoxane.