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The Effect of a Hydroxy Protecting Group on the PtCl 2 ‐Catalyzed Cyclization of Dienynes—A Novel, Efficient, and Selective Synthesis of Carbocycles
Author(s) -
Mainetti Emily,
Mouriès Virginie,
Fensterbank Louis,
Malacria Max,
MarcoContelles Jose
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20020617)41:12<2132::aid-anie2132>3.0.co;2-s
Subject(s) - cycloisomerization , chemistry , acknowledgement , catalysis , cyclooctene , combinatorial chemistry , ketone , stereochemistry , organic chemistry , medicinal chemistry , computer science , computer network
The versatile ketone C can be obtained by hydrolyzing cyclooctene B , which is formed in a PtCl 2 ‐catalyzed cycloisomerization reaction from the enyne precursor A . A carbene platinum complex is invoked in the process, which also represents one of the few efficient syntheses of functionalized cyclooctanes from acyclic precursors.