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Model Studies Towards Azadirachtin: Part 2. Construction of the Crowded C8C14 Bond by Transition Metal Chemistry
Author(s) -
Nicolaou K. C.,
Roecker A. J.,
Follmann Markus,
Baati Rachid
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20020617)41:12<2107::aid-anie2107>3.0.co;2-4
Subject(s) - transition metal , azadirachtin , chemistry , computational chemistry , combinatorial chemistry , organic chemistry , ecology , pesticide , biology , catalysis
Two strategies—one goal : Two novel methodologies for the construction of the crowded C 8 C 14 bond of azadirachtin ( 1 ) are described. The first approach to this thorny synthetic hurdle utilizes radical chemistry and furnishes model system 2 , whereas the second foray employs a nickel‐mediated coupling reaction and affords model system 3 .