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Total Synthesis of (−)‐Strychnine
Author(s) -
Nakanishi Masato,
Mori Miwako
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20020603)41:11<1934::aid-anie1934>3.0.co;2-f
Subject(s) - strychnine , palladium , catalysis , total synthesis , chemistry , combinatorial chemistry , stereochemistry , organic chemistry , biochemistry
The power of palladium catalysts is shown in a total synthesis of (−)‐strychnine ( A ). The construction of all the rings of this challenging molecule relied on Pd 0 ‐ or Pd II ‐catalyzed reactions. The final step in this efficient synthesis involved the reduction of (+)‐isostrychnine by a known method to form (−)‐strychnine.