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Biosynthesis of Polyunsaturated Fatty Acids by Polyketide Synthases
Author(s) -
Kaulmann Ursula,
Hertweck Christian
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20020603)41:11<1866::aid-anie1866>3.0.co;2-3
Subject(s) - polyketide , polyunsaturated fatty acid , psychrophile , polyketide synthase , gene cluster , biosynthesis , biochemistry , shewanella , strain (injury) , chemistry , biology , bacteria , gene , enzyme , fatty acid , genetics , anatomy
Psychrophilic marine bacteria can produce polyunsaturated fatty acids (PUFAs; see scheme). Until recently, PUFAs were known as important metabolites exclusively produced by eukaryotes with oxygen‐dependent desaturases. Surprisingly, functional analysis of a PUFA biosynthetic gene cluster from Shewanella sp. strain SCRC2738 points towards a unique mixed pathway involving a polyketide synthase.