Premium
Expanding the Reaction Scope of DNA‐Templated Synthesis
Author(s) -
Gartner Zev J.,
Kanan Matthew W.,
Liu David R.
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20020517)41:10<1796::aid-anie1796>3.0.co;2-z
Subject(s) - wittig reaction , dna , coupling reaction , aldol reaction , chemistry , heck reaction , combinatorial chemistry , gel electrophoresis , polyacrylamide , catalysis , stereochemistry , organic chemistry , biochemistry , polymer chemistry , palladium
Powerful reactions such as Wittig olefinations, nitro‐aldol additions, dipolar cycloadditions, and Heck coupling reactions can be mediated by DNA templates. The yields of several DNA‐templated reaction products are independent of the number of bases ( n =0 or 10) separating the annealed reactive groups (as an example, the denaturing polyacrylamide gel electrophoresis of a DNA‐templated Wittig reaction is shown).