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Weak Distance Dependence of Excess Electron Transfer in DNA
Author(s) -
Behrens Christoph,
Burgdorf Lars T.,
Schwögler Anja,
Carell Thomas
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20020517)41:10<1763::aid-anie1763>3.0.co;2-m
Subject(s) - thymine , dna , electron transfer , electron , irradiation , photochemistry , duplex (building) , range (aeronautics) , chemistry , electron transport chain , biophysics , dna damage , chemical physics , materials science , biology , physics , biochemistry , quantum mechanics , nuclear physics , composite material
Remote reductive repair of thymine dimers in a DNA duplex by transfer of excess electrons over a distance of up to roughly 24 Å ( n =7) has been attributed to thermally activated hopping (see scheme). Possible consequences for humans: the harmful effect of UV irradiation responsible for the development of skin cancer could potentially be reduced by compounds that bind to DNA and trigger long‐range electron transport.