Premium
Modular Building Blocks for Amino Acid Recognition in Peptides
Author(s) -
Wehner Mark,
Schrader Thomas
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20020517)41:10<1751::aid-anie1751>3.0.co;2-#
Subject(s) - modular design , amino acid , computer science , chemistry , computational biology , artificial intelligence , biochemistry , programming language , biology
A toolkit of tailor‐made peptide receptors contains building blocks for polar, aromatic, and cationic amino acids. Dipeptides are stabilized in the β‐sheet conformation by complexation with an aminopyrazole which carries a U‐shaped substituent with a properly placed binding site at its tip (see picture). The additional interaction with the amino acid side chain leads to a tenfold increase in the association constant.