Premium
Synthesis of the Protein Phosphatase 2A Inhibitor (4 S ,5 S ,6 S ,10 S ,11 S ,12 S )‐Cytostatin
Author(s) -
Bialy Laurent,
Waldmann Herbert
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20020517)41:10<1748::aid-anie1748>3.0.co;2-x
Subject(s) - stereocenter , reagent , chemistry , flexibility (engineering) , stereochemistry , combinatorial chemistry , enantioselective synthesis , organic chemistry , mathematics , catalysis , statistics
Reagent‐controlled reactions are key to the introduction of the stereocenters in the total synthesis of the cytostatin isomer 1 . The stereochemical flexibility of the synthesis allows efficient and convenient access to other isomers.