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A Chiral 1,2‐Bisphospholane Ligand with a Novel Structural Motif: Applications in Highly Enantioselective Rh‐Catalyzed Hydrogenations
Author(s) -
Tang Wenjun,
Zhang Xumu
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20020503)41:9<1612::aid-anie1612>3.0.co;2-h
Subject(s) - enantioselective synthesis , catalysis , ligand (biochemistry) , chemistry , combinatorial chemistry , stereochemistry , organic chemistry , computer science , biochemistry , receptor
TangPhos (1) is a highly efficient and practical ligand for asymmetric hydrogenations. High enantioselectivities and turnover numbers were observed in the Rh‐catalyzed hydrogenation of α ‐(acylamino)acrylic acids and α ‐arylenamides.