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In Situ Enzymatic Screening (ISES): A Tool for Catalyst Discovery and Reaction Development
Author(s) -
Berkowitz David B.,
Bose Mohua,
Choi Sungjo
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20020503)41:9<1603::aid-anie1603>3.0.co;2-d
Subject(s) - chemistry , catalysis , allylic rearrangement , in situ , amination , transition metal , enzyme catalysis , organic synthesis , combinatorial chemistry , aqueous solution , organic chemistry
Can enzymes help organic chemists identify new transition‐metal catalysts? The first example of the in situ enzymatic monitoring of an organic transformation is described. Thus, a transition‐metal‐mediated allylic‐amination reaction in the organic layer (see scheme; R= para ‐methoxyphenyl, tosyl) leads to release of ethanol which causes the spectroscopically observable formation of NADH in the aqueous phase. This approach uncovers a new Ni 0 ‐promoted route to β , γ ‐unsaturated amino acids. HMDS=1,1,1,3,3,3‐hexamethyldisilazane.