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Aldolase‐Catalyzed Asymmetric Synthesis of Novel Pyranose Synthons as a New Entry to Heterocycles and Epothilones
Author(s) -
Liu Junjie,
Wong ChiHuey
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20020415)41:8<1404::aid-anie1404>3.0.co;2-g
Subject(s) - synthon , aldolase a , epothilones , chemistry , pyranose , glyceraldehyde , stereochemistry , fructose bisphosphate aldolase , catalysis , combinatorial chemistry , enzyme , organic chemistry , dehydrogenase
Enzymatic reactions catalyzed by DERA provide the basis for a new strategy for the synthesis of novel pyranose synthons. The utility of this very convergent and effective method is demonstrated by the concise total synthesis of epothilones (see scheme; DERA=2‐deoxyribose‐5‐phosphate aldolase).