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Generation of Organotantalum Reagents and Conjugate Addition to Enones
Author(s) -
Shibata Ikuya,
Kano Takeyoshi,
Kanazawa Nobuaki,
Fukuoka Shoji,
Baba Akio
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20020415)41:8<1389::aid-anie1389>3.0.co;2-d
Subject(s) - conjugate , reagent , combinatorial chemistry , chemistry , organic chemistry , mathematics , mathematical analysis
A superior method of conjugate allylation : The transmetalation of allyltin compounds with TaCl 5 yielded active tantalum reagents for conjugate addition to enones. Even bulky allyl moieties could be introduced to enones in this manner (see scheme). Both cyclic and acyclic enones reacted facilely under extremely mild conditions.