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Stereoselective Total Synthesis of Epothilones by the Metathesis Approach Involving C9−C10 Bond Formation
Author(s) -
Sun Jian,
Sinha Subhash C.
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20020415)41:8<1381::aid-anie1381>3.0.co;2-o
Subject(s) - epothilones , stereoselectivity , metathesis , chemistry , catalysis , diene , salt metathesis reaction , total synthesis , stereochemistry , combinatorial chemistry , epothilone , organic chemistry , polymerization , polymer , natural rubber
A stereoselective synthesis of epothilone B was achieved by the metathesis of the diene 1 , by use of a new Grubbs catalyst to form the C9−C10 bond, followed by hydrogenation and deprotection of 2 ; TBS= tert ‐butyldimethylsilyl.