Premium
A Defined N‐Heterocyclic Carbene Complex for the Palladium‐Catalyzed Suzuki Cross‐Coupling of Aryl Chlorides at Ambient Temperatures
Author(s) -
Gstöttmayr Christian W. K.,
Böhm Volker P. W.,
Herdtweck Eberhardt,
Grosche Manja,
Herrmann Wolfgang A.
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20020415)41:8<1363::aid-anie1363>3.0.co;2-g
Subject(s) - carbene , palladium , aryl , steric effects , catalysis , reagent , chemistry , suzuki reaction , organic chemistry , combinatorial chemistry , polymer chemistry , medicinal chemistry , alkyl
Highly active but sterically demanding : Ambient‐temperature Suzuki cross‐coupling of aryl chlorides is possible with a palladium( 0 ) complex bearing two bulky, N‐heterocyclic carbene ligands (see structure). Nearly quantitative yields are obtained within two hours with some reagents, which makes this compound the most active catalyst known to date under these conditions.