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Enantioselective C−C Bond Formation with Titanium( IV ) Alkoxides—an Unusual Alkylation
Author(s) -
Mahrwald Rainer
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20020415)41:8<1361::aid-anie1361>3.0.co;2-s
Subject(s) - enantioselective synthesis , alkylation , chemistry , titanium , hydrogen , hydrogen bond , medicinal chemistry , catalysis , organic chemistry , molecule
Mobile hydrogen atoms : The hydrogen atoms of tertiary butyl groups are significantly more mobile than is generally assumed. Under very mild and acidic conditions aldehydes react with Ti(O t Bu) 4 to form diols in the presence of LiClO 4 and α ‐hydroxy acid (see scheme).