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Selective Complexation of N‐ Alkylpyridinium Salts: Recognition of NAD + in Water
Author(s) -
Jasper Christian,
Schrader Thomas,
Panitzky Jens,
Klärner FrankGerrit
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20020415)41:8<1355::aid-anie1355>3.0.co;2-6
Subject(s) - nad+ kinase , nicotinamide adenine dinucleotide , aqueous solution , chemistry , nicotinamide , molecule , niacinamide , combinatorial chemistry , stereochemistry , organic chemistry , enzyme
A molecular clip made of two naphthalene side walls and bisphosphonate arms selectively binds to N‐ alkylpyridinium ions in water. Through the unique potential of this clip to combine π–cation and electrostatic interactions with the hydrophobic effect, the host molecule is able to complex NAD + (nicotinamide adenine dinucleotide; see picture) efficiently in aqueous solution.