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Peptide‐Templated Saccharide Synthesis on a Solid Support
Author(s) -
Greenwell David R.,
Ibnouzaki Abdel F.,
Warriner Stuart L.
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20020402)41:7<1215::aid-anie1215>3.0.co;2-v
Subject(s) - schematic , combinatorial chemistry , computer science , peptide , simple (philosophy) , chemistry , solid phase synthesis , process (computing) , presentation (obstetrics) , stereoselectivity , biochemistry , engineering , programming language , philosophy , catalysis , medicine , epistemology , electronic engineering , radiology
“Zipping up” a carbohydrate can be as simple as glycosidation of sugar units that are attached to a solid‐phase bound peptide framework (see schematic presentation). The target disaccharides can be prepared efficiently, and the peptide template was found to influence the stereoselectivity of the glycosidation process.