Premium
Natural Product Derived Receptor Tyrosine Kinase Inhibitors: Identification of IGF1R, Tie‐2, and VEGFR‐3 Inhibitors
Author(s) -
Stahl Petra,
Kissau Lars,
Mazitschek Ralph,
Giannis Athanassios,
Waldmann Herbert
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20020402)41:7<1174::aid-anie1174>3.0.co;2-v
Subject(s) - receptor tyrosine kinase , tyrosine kinase , cancer research , natural product , ror1 , insulin like growth factor 1 receptor , proto oncogene tyrosine protein kinase src , tropomyosin receptor kinase c , platelet derived growth factor receptor , kinase , receptor , chemistry , biology , microbiology and biotechnology , biochemistry , growth factor
Blood and lymph vessel growth is regulated by Tie‐2 and the VEGFR‐3 receptor tyrosine kinases. These proteins also play major roles in the growth and metastasis of cancers. A novel class of inhibitors of these signal‐transducing proteins, and of the IGF1R kinase (such as 1 ), is identified from a natural product derived compound library. This discovery opens up new opportunities for the development of antitumor agents.