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Cover Picture: Angew. Chem. Int. Ed. 6/2002
Author(s) -
Lewis Warren G.,
Green Luke G.,
Grynszpan Flavio,
Radić Zoran,
Carlier Paul R.,
Taylor Palmer,
Finn M. G.,
Sharpless K. Barry
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20020315)41:6<875::aid-anie875>3.0.co;2-y
Subject(s) - cover (algebra) , cycloaddition , chemistry , electrophorus , azide , glutaraldehyde , stereochemistry , combinatorial chemistry , organic chemistry , biochemistry , engineering , mechanical engineering , torpedo , acetylcholine receptor , receptor , catalysis
The cover picture shows the electric eel, Electrophorus electricus , a source for commercially available acetylcholinesterase. In an experiment described by K. B. Sharpless and M. G. Finn and co‐workers on pp. 1053–1057, a femtomolar inhibitor was assembled by the enzyme from a collection of building blocks containing azide and alkyne functional groups, shown floating in solution. The templated 1,3‐dipolar cycloaddition reaction, producing the inhibitor, is represented by the flare of light at the center of the image.