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The First Water‐Soluble Copper( I ) Calix[6]arene Complex Presenting a Hydrophobic Ligand Binding Pocket: A Remarkable Model for Active Sites in Metalloenzymes
Author(s) -
Rondelez Yannick,
Bertho Gildas,
Reinaud Olivia
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20020315)41:6<1044::aid-anie1044>3.0.co;2-0
Subject(s) - calixarene , copper , chemistry , ligand (biochemistry) , valence (chemistry) , active center , combinatorial chemistry , tris , stereochemistry , enzyme , organic chemistry , molecule , receptor , biochemistry
Remarkable stabilization of a copper( i) center is evident in the tris(sulfonated) calixarene‐based complex shown. This complex is truly biomimetic as it is soluble in water and also has a free valence where CO can bind. Thus it imitates the first coordination sphere encountered in copper enzymes and the hydrophobic microenvironment of the active site.