Premium
Diastereoselective Asymmetric Nitro‐Aldol Reaction of α ‐Amino Aldehydes under High Pressure without Catalyst
Author(s) -
Misumi Yukihiro,
Matsumoto Kiyoshi
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20020315)41:6<1031::aid-anie1031>3.0.co;2-k
Subject(s) - aldol reaction , nitro , catalysis , stereoselectivity , chemistry , high pressure , organic chemistry , medicinal chemistry , physics , alkyl , engineering physics
Under pressure , the nitro‐aldol reaction of ( S )‐ N , N ‐dibenzylphenylalaninal and related compounds with nitroalkanes was highly stereoselective (see scheme; R 1 , R 2 = Me, H; R = Ph, Me, i Pr, i Bu). This reaction is very convenient, as it only requires high pressure and no catalyst.