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Dynamics and Energetics of Hole Trapping in DNA by 7‐Deazaguanine
Author(s) -
Lewis Frederick D.,
Liu Jianqin,
Liu Xiaoyang,
Zuo Xiaobing,
Hayes Ryan T.,
Wasielewski Michael R.
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20020315)41:6<1026::aid-anie1026>3.0.co;2-t
Subject(s) - thymine , guanine , energetics , trapping , kinetic energy , base pair , chemistry , dna , chemical physics , spectroscopy , charge (physics) , atomic physics , physics , thermodynamics , biology , nucleotide , biochemistry , ecology , quantum mechanics , gene
A deep hole trap is 7‐deazaguanine (Z)—according to time‐resolved transient absorption spectroscopy and kinetic modeling—for hole transport in DNA from a guanine (G) to a Z base across one or two intervening adenine–thymine base pairs. The Gibbs energy for hole transport from G to Z was determined to be −0.19 eV, much larger than values for GG or GGG sites. Thus Z effectively prevents charge migration in DNA.