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Aluminum‐Catalyzed Asymmetric Addition of TMSCN to Aromatic and Aliphatic Ketones Promoted by an Easily Accessible and Recyclable Peptide Ligand
Author(s) -
Deng Hongbo,
Isler Markus P.,
Snapper Marc L.,
Hoveyda Amir H.
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20020315)41:6<1009::aid-anie1009>3.0.co;2-f
Subject(s) - trimethylsilyl cyanide , catalysis , chemistry , ligand (biochemistry) , enantioselective synthesis , selectivity , trimethylsilyl , combinatorial chemistry , peptide , cyanide , organic chemistry , receptor , biochemistry
Easily prepared peptide‐based ligands efficiently promote the Al‐catalyzed enantioselective addition of trimethylsilyl cyanide (TMSCN) to aromatic, aliphatic, cyclic, and acyclic ketones (see scheme for an example). The chiral ligands can be readily recovered and reused without loss of activity or selectivity.