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Mimicking Metallophosphatases: Revealing a Role for an OH Group with No Libido
Author(s) -
Forconi Marcello,
Williams Nicholas H.
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20020301)41:5<849::aid-anie849>3.0.co;2-7
Subject(s) - libido , foundation (evidence) , group (periodic table) , psychology , library science , sociology , computer science , chemistry , political science , psychoanalysis , law , organic chemistry
An intramolecular OH group can become much more effective in promoting phosphate hydrolysis when combined with multiple interactions in a model for the metallophosphatase active site (see picture; tacn=1,4,7‐triazacyclononane).