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A Method for Thermal Generation of Aryloxyl Radicals at Ambient Temperatures: Application to Low‐Density Lipoprotein (LDL) Oxidation
Author(s) -
Paul Thomas,
Ingold Keith U.
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20020301)41:5<804::aid-anie804>3.0.co;2-6
Subject(s) - radical , chemistry , decomposition , thermal decomposition , arrhenius equation , photochemistry , inorganic chemistry , organic chemistry , activation energy
ARTS in chemistry : Aryloxymethyl hyponitrites provide the first aryloxyl radical thermal sources ( ARTS ) which generate a well‐defined flux of aryloxyl radicals (ArO . ) at room temperature [Eq. (1)]. These novel compounds can be used for quantitative studies on reactions of ArO . with biomolecules, as exemplified by the PhO . ‐mediated oxidation of human low‐density lipoprotein.