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A (6‐4) Photolyase Model: Repair of DNA (6‐4) Lesions Requires a Reduced and Deprotonated Flavin
Author(s) -
Cichon Michaela K.,
Arnold Simone,
Carell Thomas
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20020301)41:5<767::aid-anie767>3.0.co;2-b
Subject(s) - photolyase , flavin group , oxetane , deprotonation , pyrimidine dimer , chemistry , pyrimidine , covalent bond , photochemistry , dna , electron transfer , stereochemistry , dna repair , combinatorial chemistry , biochemistry , enzyme , organic chemistry , ion
Photolyase‐catalyzed repair of pyrimidine (6‐4) photoadducts was modeled with synthetic, covalently linked flavin–oxetane 1 . The repair reaction (oxetane splitting) requires the reduced flavin in its deprotonated form. The key step of the repair reaction involves an electron transfer from the flavin to the oxetane.