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Catalytic, Enantioselective Syntheses of β ‐Lactones—Versatile Synthetic Building Blocks in Organic Chemistry
Author(s) -
Schneider Christoph
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20020301)41:5<744::aid-anie744>3.0.co;2-v
Subject(s) - enantioselective synthesis , catalysis , organic synthesis , combinatorial chemistry , chemistry , optically active , ring (chemistry) , functional group , organic chemistry , polymer
Owing to their highly strained ring system and interesting functional group , β ‐lactones possess significant synthetic potential. Recently, novel methods have been developed to synthesize these valuable building blocks very efficiently by catalytic, enantioselective reactions, such as [2+2] cycloadditions, starting from simple precursors. These processes also offer an attractive alternative for the synthesis of optically active β ‐hydroxy and β ‐amino acids (see scheme).