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Iron‐Catalyzed Cross‐Coupling Reactions of Alkyl‐Grignard Reagents with Aryl Chlorides, Tosylates, and Triflates
Author(s) -
Fürstner Alois,
Leitner Andreas
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20020215)41:4<609::aid-anie609>3.0.co;2-m
Subject(s) - aryl , reagent , alkyl , catalysis , chemistry , coupling reaction , catalytic cycle , coupling (piping) , grignard reagent , organic chemistry , medicinal chemistry , combinatorial chemistry , materials science , metallurgy
Aryl chlorides are better substrates than the corresponding bromides or iodides in the presented cross‐coupling with alkyl Grignard reagents that is catalyzed by iron salts (see scheme); even aryl tosylates are converted efficiently. This situation is attributed to a novel catalytic cycle, which probably involves iron complexes with formally negative oxidation states (probably Fe −II ).