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RNA Two‐State Conformation Equilibria and the Effect of Nucleobase Methylation
Author(s) -
Höbartner Claudia,
Ebert MarcOlivier,
Jaun Bernhard,
Micura Ronald
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20020215)41:4<605::aid-anie605>3.0.co;2-1
Subject(s) - nucleobase , rna , methylation , rna methylation , dna methylation , chemistry , computational biology , dna , genetics , biology , biochemistry , gene , gene expression , methyltransferase
One sequence, but two conformations! The coexistence of conformers has been ascertained for a series of RNA oligonucleotides. The monomolecular conformation equilibria are shifted significantly by methylation of selected nucleobases; the methylation of the studied sequences corresponds to that of the naturally occurring helix 45 at the 3′‐end in the small subunit of ribosomal RNA.