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Total Synthesis of the Presumed Amphidinolide A
Author(s) -
Lam Hon Wai,
Pattenden Gerald
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20020201)41:3<508::aid-anie508>3.0.co;2-7
Subject(s) - stille reaction , diastereomer , intramolecular force , chemistry , stereochemistry , natural product , total synthesis , organic chemistry , catalysis
Judicious use of both inter‐ and intramolecular Stille reactions was required in the synthesis of 1 , the putative stereostructure of amphidinolide A. Compound 1 was shown to be a diastereomer of the natural product.