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Biomimetic NAD + Models for Tandem Cofactor Regeneration, Horse Liver Alcohol Dehydrogenase Recognition of 1,4‐NADH Derivatives, and Chiral Synthesis
Author(s) -
Lo H. Christine,
Fish Richard H.
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20020201)41:3<478::aid-anie478>3.0.co;2-k
Subject(s) - cofactor , alcohol dehydrogenase , nad+ kinase , chemistry , tandem , alcohol , stereochemistry , alcohol oxidoreductase , horse , catalysis , dehydrogenase , biocatalysis , enzyme , combinatorial chemistry , organic chemistry , reaction mechanism , biology , materials science , paleontology , composite material
Two tandem catalysis approaches : first, a cofactor regeneration procedure with an NAD + model and [Cp*Rh(bpy)H] + , which was formed in situ, provided the 1,4‐NADH analogue 1 . Cofactor 1 was then used with horse liver alcohol dehydrogenase (HLADH) for the conversion of prochiral ketones into chiral alcohols (e.g. 2 → 3 ).