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A New Approach to Osmium‐Catalyzed Asymmetric Dihydroxylation and Aminohydroxylation of Olefins
Author(s) -
Andersson Malin A.,
Epple Robert,
Fokin Valery V.,
Sharpless K. Barry
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20020201)41:3<472::aid-anie472>3.0.co;2-7
Subject(s) - dihydroxylation , osmium , catalysis , catalytic cycle , chemistry , hydroxylation , enantioselective synthesis , combinatorial chemistry , organic chemistry , ruthenium , enzyme
Simple hydroxyamino acid derivatives act as chiral ligands in osmium‐catalyzed dihydroxylation and aminohydroxylation of olefins (see scheme). These are the first examples of asymmetric osmium‐catalyzed processes proceeding in the second catalytic cycle with resident ligands on the metal center.