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Synthetic Studies on the Sulfur‐Cross‐Linked Core of Antitumor Marine Alkaloid, Discorhabdins: Total Synthesis of Discorhabdin A
Author(s) -
Tohma Hirofumi,
Harayama Yuu,
Hashizume Miki,
Iwata Minako,
Egi Masahiro,
Kita Yasuyuki
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20020118)41:2<348::aid-anie348>3.0.co;2-i
Subject(s) - alkaloid , sulfur , core (optical fiber) , total synthesis , construct (python library) , chemistry , stereochemistry , engineering , organic chemistry , computer science , telecommunications , programming language
A concise and efficient method to construct the characteristic sulfur‐cross‐linked core of an unprecedented antitumor marine alkaloid, discorhabdins, has been developed. By utilizing this methodology the first total synthesis of (±)‐discorhabdin A ( 1 ) has been achieved.