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Foldamers as Dynamic Receptors: Probing the Mechanism of Molecular Association between Helical Oligomers and Rodlike Ligands
Author(s) -
Tanatani Aya,
Hughes Thomas S.,
Moore Jeffrey S.
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20020118)41:2<325::aid-anie325>3.0.co;2-1
Subject(s) - oligomer , chemistry , association (psychology) , mechanism (biology) , stereochemistry , crystallography , biophysics , polymer science , polymer chemistry , physics , philosophy , biology , epistemology , quantum mechanics
A dynamic binding mechanism allows the association of dumbbell‐shaped ligand 2 with helical folded oligo( m ‐phenyleneethynylene)s 1 (see schematic representation). Association constants are oligomer length specific, with a maximum value for the icosamer and docosamer. These oligomers have helical conformations that are highly shape‐complementary to 1 ; shorter and longer oligomers exhibit association constants roughly an order of magnitude smaller.