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A Convenient Oxime‐Carbapalladacycle‐Catalyzed Suzuki Cross‐Coupling of Aryl Chlorides in Water
Author(s) -
Botella Luis,
Nájera Carmen
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20020104)41:1<179::aid-anie179>3.0.co;2-o
Subject(s) - aryl , oxime , phenylboronic acid , chemistry , potassium carbonate , catalysis , solvent , bromide , suzuki reaction , base (topology) , organic chemistry , coupling reaction , potassium bromide , polymer chemistry , medicinal chemistry , palladium , mathematical analysis , alkyl , mathematics
Refluxing water is a good solvent for the coupling reactions of aryl and heteroaryl chlorides with phenylboronic acid (see scheme; FG=functional group). The reactions use oxime‐derived palladacycles 1 as thermally stable catalysts, potassium carbonate as base, and tetrabutylammonium bromide (TBAB), and can be carried out in the presence of air.