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High‐Throughput Screening of Enantioselective Catalysts by Immunoassay
Author(s) -
Taran Frédéric,
Gauchet Cécile,
Mohar Barbara,
Meunier Stéphane,
Valleix Alain,
Renard Pierre Yves,
Crémi Christophe,
Grassi Jacques,
Wagner Alain,
Mioskowski Charles
Publication year - 2002
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20020104)41:1<124::aid-anie124>3.0.co;2-r
Subject(s) - enantioselective synthesis , mandelic acid , immunoassay , formic acid , chemistry , combinatorial chemistry , catalysis , high throughput screening , organic chemistry , chromatography , biochemistry , antibody , immunology , biology
More than 1000 yields and ee determinations are possible per day using an immunoassay. This highly efficient screening method is based on the remarkable binding specificity of antibodies. It has been employed in the development of straightforward procedures for the direct conversion of α ‐keto acids into chiral α ‐hydroxy acids, for which the enantioselective reduction of benzoyl formic acid to mandelic acid serves as a model reaction (see scheme).