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Consecutive Three‐ and Four‐Component Coupling Reactions with Anions Generated from a Butane Diacetal Desymmetrized Glycolic Acid Derivative
Author(s) -
Dixon Darren J.,
Ley Steven V.,
Rodríguez Félix
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20011217)40:24<4763::aid-anie4763>3.0.co;2-d
Subject(s) - glycolic acid , butane , derivative (finance) , stereocenter , chemistry , component (thermodynamics) , coupling reaction , coupling (piping) , organic chemistry , combinatorial chemistry , materials science , biology , enantioselective synthesis , genetics , thermodynamics , physics , bacteria , financial economics , economics , metallurgy , catalysis , lactic acid
Up to five new stereogenic centers (see 2 ) can be formed in one‐pot consecutive three‐ and four‐component coupling reactions starting from a butane diacetal desymmetrized glycolic acid derivative 1 . Highly functionalized α ‐hydroxy acid derivatives are obtained in an easy, fast, clean, and efficient way. LHMDS = lithium hexamethyldisilazide.