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From Solutions to Surfaces: A Novel Molecular Imprinting Method Based on the Conformational Changes of Boronic‐Acid‐Appended Poly( L ‐lysine)
Author(s) -
Friggeri Arianna,
Kobayashi Hideki,
Shinkai, Seiji,
Reinhoudt David N.
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20011217)40:24<4729::aid-anie4729>3.0.co;2-m
Subject(s) - boronic acid , fructose , molecular imprinting , lysine , chemistry , polymer , imprinting (psychology) , polymer chemistry , combinatorial chemistry , organic chemistry , amino acid , selectivity , biochemistry , catalysis , gene
The dominant solution‐phase conformation of a polymer can be fixed to a surface (see scheme). Boronic acid appended poly( L ‐lysine) assumes different conformations in the presence of D ‐glucose or D ‐fructose. When the polymer–glucose complex is anchored to a gold surface, an imprinted interface with “molecular memory” for glucose over fructose can be prepared.