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Design and Synthesis of a Peptide That Binds Specific DNA Sequences through Simultaneous Interaction in the Major and in the Minor Groove
Author(s) -
Vázquez M. Eugenio,
Caamaño Ana M.,
MartínezCostas José,
Castedo Luis,
Mascareñas José L.
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20011217)40:24<4723::aid-anie4723>3.0.co;2-l
Subject(s) - minor groove , schematic , dna , bivalent (engine) , peptide , minor (academic) , biophysics , protein–dna interaction , chemistry , stereochemistry , computational biology , combinatorial chemistry , dna binding protein , biology , biochemistry , engineering , transcription factor , metal , organic chemistry , electronic engineering , gene , political science , law
A bivalent system capable of binding to hybrid DNA sites through simultaneous interaction in the major and the minor groove (see schematic representation) is formed by appropriate linking of the basic region of a b‐ZIP protein (GCN4) to a tripyrrole related to the antibiotic distamycin.