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The Biosynthesis of Vancomycin‐Type Glycopeptide Antibiotics—The Order of the Cyclization Steps
Author(s) -
Bischoff Daniel,
Pelzer Stefan,
Bister Bojan,
Nicholson Graeme J.,
Stockert Sigrid,
Schirle Markus,
Wohlleben Wolfgang,
Jung Günther,
Süssmuth Roderich D.
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20011217)40:24<4688::aid-anie4688>3.0.co;2-m
Subject(s) - glycopeptide , glycopeptide antibiotic , biosynthesis , antibiotics , vancomycin , stereochemistry , chemistry , combinatorial chemistry , biochemistry , biology , bacteria , gene , staphylococcus aureus , genetics
Linear and bicyclic glycopeptides occur as intermediates in the biosynthesis of the aglycon of glycopeptide antibiotics of the type shown. Considering the structures of these peptides and those of previously isolated analogues, the sequence of the three oxidative ring‐closing steps can be deduced for type‐I and type‐II glycopeptide antibiotics. Thus, comprehensive insight into the assembly of the aglycon is achieved for the first time.